Revolutionary Cell Separation Technology
For A Patient Every Cell Counts
Removal of B cells while retaining CD4+ T cells
Typical Results Achieved
97% Removal of B cells (CD19)
99% Retention T cells (CD4)
High Quality Performance
- Add Beads to Sample
- Mix for 5 minutes
- On magnet for 5 minutes
- Remove depleted suspension
Existing Cell Samples
After RBI-Bead Cleansing
With virtuality no loss of desired cell
RBI-beads Out-Perform the Competition
Cell Recovery Single Step Directly in Source Material
| GOAL | RESULT | |||
| Sample | Retain | Purge | Retained | Purged |
| Whole Blood | Lymphocytes | Granulocytes | 98% | 99% |
| PBMC | T cells (CD4) | T cells (CD8) | 98% | 96% |
| B cells (CD19) | >97% | 97% | ||
| PBMC | T cells (CD8) | T cells (CD4) | 97% | 100% |
| B cells (CD19) | >97% | 97% | ||
Percentages ±3%
Cell Recovery Remains HIGH in Sequential Enrichment Steps
| No. times | RBI-bead Cell recovery | Competitive Best Case Cell recovery |
| Triple Pass | 93% - 15 min | 34% - 2.25 hrs** |
| Single Pass | 98% - 5 min | 70% - 45 min (reported 30%-70%) |
*Comparison to top two competitors marketing literature: 60%, 70-75% (ThermoFisher's dynabeads, and Miltenyi), with multiple other primary reference sources stating 30-50% yield each pass.
Technology Application Benefits
- Application of this next generation technology will enable access to cell therapy for more patients.
- It will lower costs and improve quality of therapeutic and patient monitoring.
- Fewer apheresis harvest required reducing harvest and process time
- Speedier processes will save lives, and access for the sickest patients.
- A triple increase in yield from a single draw moves will have significant benefits for the patient.
A Good Product Starts with Quality Cells
RBI Beads for Cell Therapy Manufacturing & Patient Monitoring
- Our magnetic beads will reduce the loss of critical target cells in harvesting, enrichment, and in isolation/purification processes of therapeutic cells.
- Will reduce costs and impact production time and quality.
- Improving manufacturing will positively impacting patient access.
- Increased cell recovery in each and every draw – results in fewer and smaller draws required from the patient.
RBI Beads can be directly applied to blood samples or Leucopaks
